The Lady Davis Institute & The McGill University-Génome Québec Innovation Centre present:

A McGill Distinguished Lecture in Human Genetics Exploration of gene regulatory mechanisms across eukaryotes via a compendium of DNA and RNA motifs
Dr. Tim Hughes

Professor, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto

April 11, 2013, 4:00-5:30pm

Charles Martin Amphitheatre, McIntyre Medical Sciences Building

3655 Promenade Sir William Osler, Montreal, Quebec

A challenge to our understanding of genome function is lack of accurate and complete knowledge of the sequence preferences of DNA and RNA binding proteins. Current work in Dr. Tim Hughes’ laboratory is aimed at using in vitro assays to catalogue motifs on a genomic scale, thus separating the intrinsic activities of the proteins from confounding effects present in vivo. These data are invaluable in understanding how cells recognize genomic features, how gene regulatory networks are organized, and nucleic acid-binding proteins regulate healthy and disease states.

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