Congratulations to all the outstanding Faculty of Medicine and Health Sciences principal investigators and their teams who were awarded grants totalling $43M in the latest round of funding from the Canadian Institutes of Health Research (CIHR), which increased its total funding in this competition from $325M to $411M.
Project Grant: Fall 2024 – FMHS recipients (listed in alphabetical order by PI)
Laurent Azoulay, PhD, Associate Professor in the Department of Epidemiology, Biostatistics and Occupational Health and Gerald Bronfman Department of Oncology
Assessing the long-term carcinogenic effects of glucagon-like peptide-1 receptor agonists on thyroid, pancreatic, and biliary tract cancers: an international, multi-site cohort study
Jill Baumgartner, PhD, Professor Department of Epidemiology, Biostatistics & Occupational Health
Co-producing knowledge on neighbourhood heat and its impacts on child mental health and cognition
Xiaoqian Chai, PhD, Assistant Professor in the Department of Neurology and Neurosurgery
Precision multi-modal brain imaging of high-level cognitive functional network development in autism via ultra-high field MRI
Guojun Chen, PhD, Assistant Professor in the Department of Biomedical Engineering
Bioresponsive Immunomodulator Nanocomplex for Selective Immunoengineering to Treat Lymph Node Metastasis
Matthew Cheng, MD, Assistant Professor, Department of Medicine
A Randomized Controlled Trial of Oral Antimicrobial Therapy for Patients with Staphylococcus aureus Bacteremia: The Early Oral Switch Domain in the Staphylococcus aureus Network Adaptive Trial (EOS-SNAP)
Anne Cockcroft, MD, Professor, Department of Family Medicine
Youth co-design prevention of gendered personal and interpersonal violence in Botswana
Inés Colmegna, MD, Associate Professor, Department of Medicine
Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells
Raquel Cuella Martin, PhD, Assistant Professor, Department of Human Genetics
Systematic interrogation of the USP28-53BP1-dependent p53 regulation
Alain Dagher, MD, Professor, Neurology and Neurosurgery
Effects of GLP1-agonist induced weight loss on brain, metabolic, and cerebrovascular health measures
Stella S. Daskalopoulou, PhD, Professor, Department of Medicine
Clinical Investigation – A: Reproduction, Maternal, Child and Youth Health 2
Sonia Victoria del Rincon, PhD, Associate Professor, Gerald Bronfman Department of Oncology
Understanding the role of the MNK/eIF4E axis in cells of the tumour microenvironment to improve outcomes for patients with DLBCL
Gustavo Duque, MD, PhD, Professor, Department of Medicine
Investigating the Diagnostic and Therapeutic Role of the Kynurenine Pathway in Osteosarcopenia
Jérôme Fortin, PhD, Assistant Professor, Department of Neurology and Neurosurgery
Characterizing and improving new treatments for IDH-mutant diffuse gliomas
Céline Gélinas, RN, PhD, Professor Ingram School of Nursing
Prévalence, facteurs et trajectoires de douleur chronique à la suite d’un séjour aux soins intensifs: Du congé à 12 mois
Vincent Giguere, PhD, Professor of Biochemistry
Investigating the molecular mechanisms dictating the oncogenic action of HOXB13 in prostate cancer
Christina Greenaway, MD, Associate Professor, Department of Medicine
Getting to hepatitis B elimination in Canada: Where are the gaps and how best to fill them?
John Hanrahan, PhD, Professor, Department of Physiology
Wildfire smoke inhibition of CFTR: mechanisms and mitigation
Sabah Hussain, MD, PhD Professor, Department of Medicine
Regulation of skeletal muscle and peroxisomal homeostasis by Depp1 protein
Bertrand Jean-Claude, PhD, Professor, Department of Medicine
Engineering metabolically stable molecules toward tandem targeting of EGFR, its variant EGFRvIII and DNA for killing stem cells and preventing recurrence in the treatment of glioblastom multiforme (GBM)
Loydie Jerome-Majewska, PhD, Professor, Department of Pediatrics
Mouse Models of Spliceosomopathies: The Role of Snrpb in Axial Development
Wassim Kassouf, MD, Professor, Department of Surgery
Unravelling immune-microbiome networks in radiation-based organ-preserving therapies for muscle-invasive bladder cancer
Lawrence Kazak, PhD, Assistant Professor, Department of Biochemistry
Allosteric activation of the alkaline phosphatase TNAP: from basic biology to therapeutic potential
Todd C. Lee, MD, Associate Professor, Department of Medicine
An international platform for finding the optimal therapies for Pneumocystis jirovecii pneumonia: The PCP Platform
Ivan Litvinov, MD, PhD, Associate Professor, Department of Medicine
Co-creating and implementing integrated dermatology care and augmenting skin research in Quebec northern Indigenous communities
Austen Milnerwood, PhD, Associate Professor, Department of Neurology and Neurosurgery
LRRK2 mutant mechanisms & targeting for PD
Lisa Münter, PhD, Assistant Professor, Department of Pharmacology and Therapeutics
Physiological functions of the amyloid precursor protein (APP) in endothelial cells
Madhukar Pai, MD, PhD, Professor, Department of Epidemiology, Biostatistics and Occupational Health
Why are women at greater risk for multi-drug resistant tuberculosis?
Morag Park, PhD, Professor, Department of Biochemistry
Targeting drug tolerant persister cells in poor outcome breast cancer
Basil Petrof, MD, Professor, Department of Medicine
The role of trained macrophages in dystrophic diaphragm pathology
Adrien Peyrache, PhD, Assistant Professor, Department of Neurology and Neurosurgery
How dysfunction of hippocampal sharp wave-ripples leads to cognitive impairment in a mouse model of Christianson syndrome
Louise Pilote, MD, PhD, Professor, Department of Medicine
Role of Sex and Gender on Hypertension-mediated Multi-organ Damage
Jean-Baptiste Poline, PhD, Associate Professor in the Department of Neurology and Neurosurgery
Characterizing and predicting PD biological stages with neuroimaging across global populations
Dieter Reinhardt, PhD, Professor, Department of Anatomy and Cell Biology
Role of fibronectin in skeletal development and associated disease
Christel Renoux, MD, PhD, Associate Professor, Department of Neurology and Neurosurgery
Towards equitable hypertension care: sex differences in blood pressure targets, variability and trajectories
Stéphane Richard, PhD, Professor, Department of Medicine and Gerald Bronfman Department of Oncology
Epigenetic modulation to enhance CD8+ T cells for improved antitumour activity
April Rose, MD, PhD, Assistant Professor, Gerald Bronfman Department of Oncology
Exploring novel protein interactions in RAF mutant tumors to reveal new therapeutic opportunities
Marc Roig, PhD, Professor, School of Physical and Occupational Therapy
Preventing post-stroke cognitive impairment and dementia with multimodal exercise training
Justin Sanders, MD, Associate Professor, Department of Family Medicine
AI-generated electronic health record summaries to promote high-quality communication and care in serious illness: a feasibility trial
Abhinav Sharma, MD, PhD, Assistant Professor, Department of Medicine
Delivering Evidence-Based Care Using Artificial Intelligence to Patients with Diabetes and CardioVascular Comorbidities: From Proof of Concept to Multi-Centre Expansion (DECIDE-CV-2)
Nahum Sonenberg, PhD, Professor, Department of Biochemistry
Dysregulated insulin signalling in the pathophysiology of ASD
Daniel Taliun, PhD, Assistant Professor, Department of Human Genetics
PheWeb-2.0: an interactive tool for generating and testing hypotheses on sex-biased genetic variant-trait associations in large-scale population-based studies
Rhian Touyz, MBBCh, PhD, Professor, Department of Medicine
Rho kinase as a novel therapeutic target in small vessel disease and vascular dementia – insights from a Notch3 disease
Scott Weichenthal, PhD, Professor, Department of Epidemiology, Biostatistics, and Occupational Health
Outdoor Aeroallergen Concentrations as Overlooked Environmental Risk Factors for Acute Cardiovascular Events: High Resolution Exposure Modelling and Epidemiological Analyses in Canadian Cities
Pia Wintermark, MD, Associate Professor, Department of Pediatrics
Sildenafil to repair the injured brain of critically-ill neonates with hypoxic-ischemic encephalopathy
Oriana Hoi Yun Yu, MD, Associate Professor (Clinical), Department of Medicine
The association between levothyroxine treatment and the risk of metabolic dysfunction-associated steatotic liver disease among people with subclinical hypothyroidism
Priority Announcements – FMHS recipients (listed in alphabetical order by PI)
- Sara Ahmed, Associate Professor, School of Physical and Occupational Therapy
INtegrated Smart ImplemeNtation of Care (IN-SINC) in Rehabilitation - Jérôme Fortin, Assistant Professor, Department of Neurology and Neurosurgery
Early Career Investigator in Cancer Prize: Characterizing and improving new treatments for IDH-mutant diffuse gliomas - William D Foulkes, MB.BS, PhD, Distinguished James McGill Professor, Departments of Human Genetics, Medicine and Oncology; Departmental Chair of Human Genetics
Investigating and targeting pathogenic variants in DICER1 tumour predisposition syndrome
- Claire Godard-Sebillotte, MD, PhD, Assistant Professor, Department of Medicine
Améliorer l’équité en première ligne pour les personnes avec troubles neurocognitifs majeurs: Une étude à méthodes mixtes axée sur le patient - Wei-Hsiang Huang, PhD, Assistant Professor, Department of Neurology and Neurosurgery
Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models - Anita Koushik, PhD, Professor, Gerald Bronfman Department of Oncology
A prospective study of risk stratification with epigenetic markers to improve clinical management of cervical precancerous lesions - Mathieu Maheu-Giroux, PhD, Associate Professor Department of Epidemiology, Biostatistics and Occupational Health
Global, regional, and national estimates of trends in HIV stigma and discrimination - Dadar Mahsa, PhD, Assistant Professor, Department of Psychiatry
Yves Joanette Award of Excellence in Research in Aging: Developing a novel ex vivo acquisition and analysis pipeline to understand the neuropathological basis of magnetic resonance imaging findings: application in Alzheimer’s disease - Thomas Mavrakanas, MD, Associate Professor, Department of Medicine
Effect of Canagliflozin on Peritoneal Function and Fibrosis in Patients on Peritoneal Dialysis: a proof-of-concept randomized crossover clinical trial (CAN-PD trial) - Joanna Przybyl, PhD, Assistant Professor, Department of Surgery
Towards improving treatment outcomes in leiomyosarcoma through multi-omic liquid biopsy - Shaifali Sandal, MD, Associate Professor, Department of Medicine
Disaster risk reduction and management in kidney care to foster health system resilience - Giada Sebastiani, MD, Professor, Department of Medicine
ELITE-2D: Enhancing Liver Health for People with Type 2 Diabetes through Patient-Centred Strategies
Related:
CIHR Fall 2024 results (CIHR website)
Fall 2024 Project Grant competition results – increased investment (CIHR announcement)
Six principal investigators from The Neuro receive CIHR grants
Five GCI Researchers Secure $5.2M in CIHR Funding